Chuankai Zhang
Physician/Postdoctoral Fellow
I obtained his PhD from the Institute for Cardiovascular Prevention (IPEK) at Ludwig Maximilian University (LMU), where I extensively researched the complex mechanisms governing immune responses related to atherosclerosis. My research focuses on how the B cell immune response in artery tertiary lymphoid organs (ATLOs) interacts with atherosclerosis. Through this innovative work, we aim to uncover the role of ATLOs in atherosclerosis and define it as a bona fide autoimmune disease.
PUBLICATIONS
8.Y. Ran et al. Regulator of G-protein signaling 14 (RGS14) promotes cancer growth in hepatocellular carcinoma.Cancer Genetics 294-295, 80-89.doi:(2025)
7.Zhang Y, Liu G, Zeng Q, Wu W, Lei K, Zhang C, Tang M, Zhang Y, Xiang X, Tan L, Cui R, Qin S, Song X, Yin C, Chen Z, Kuang M. CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis. Cancer Cell. 2024 Aug 12;42(8):1370-1385.e9. doi: 10.1016/j.ccell.2024.07.006. PMID: 39137726.
6.Zhihua Wang, Xi Zhang, Shu Lu, Chuankai Zhang, Zhe Ma, Rui Su, Yuanfang Li, Ting Sun, Yutao Li, Mingyang Hong, Xinyi Deng, Mohammad Rafiee Monjezi, Michael Hristov, Sabine Steffens, Donato Santovito, Klaus Dornmair, Klaus Ley, Christian Weber, Sarajo K. Mohanta, Andreas J. R. Habenicht & Changjun Yin. Pairing of single-cell RNA analysis and T cell antigen receptor profiling indicates breakdown of T cell tolerance checkpoints in atherosclerosis. Nat Cardiovasc Res 2, 290–306 (2023). https://doi.org/10.1038/s44161-023-00218-w
5.Wang Z, Zhang X, Zhang C, Li Y, Lu S, Mohanta S, Weber C, Habenicht A, Yin C. Combined Single-Cell RNA and Single-Cell α/β T Cell Receptor Sequencing of the Arterial Wall in Atherosclerosis. Methods Mol Biol. 2022;2419:727-746. doi: 10.1007/978-1-0716-1924-7_44. PMID: 35237998.
4.Zhang X, Wang Z, Zhang C, Li Y, Lu S, Steffens S, Mohanta S, Weber C, Habenicht A, Yin C. Laser Capture Microdissection-Based mRNA Expression Microarrays and Single-Cell RNA Sequencing in Atherosclerosis Research. Methods Mol Biol. 2022;2419:715-726. doi: 10.1007/978-1-0716-1924-7_43. PMID: 35237997.
3.Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Borodovsky A, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, Habenicht AJR. ApoE attenuates unresolvable inflammation by complex formation with activated C1q. Nat Med. 2019 Mar;25(3):496-506. doi: 10.1038/s41591-018-0336-8. Epub 2019 Jan 28. Erratum in: Nat Med. 2019 Mar;25(3):529. doi: 10.1038/s41591-019-0378-6. PMID: 30692699; PMCID: PMC6420126.
2.Zhang C, Zhang Y, Ding W, Lin Y, Huang Z, Luo Q. MiR-33a suppresses breast cancer cell proliferation and metastasis by targeting ADAM9 and ROS1. Protein Cell. 2015 Dec;6(12):881-9. doi: 10.1007/s13238-015-0223-8. Epub 2015 Oct 27. PMID: 26507842; PMCID: PMC4656205.
1.Mohanta SK, Peng L, Li Y, Lu S, Sun T, Carnevale L, Perrotta M, Ma Z, Förstera B, Stanic K, Zhang C, Zhang X, Szczepaniak P, Bianchini M, Saeed BR, Carnevale R, Hu D, Nosalski R, Pallante F, Beer M, Santovito D, Ertürk A, Mettenleiter TC, Klupp BG, Megens RTA, Steffens S, Pelisek J, Eckstein HH, Kleemann R, Habenicht L, Mallat Z, Michel JB, Bernhagen J, Dichgans M, D'Agostino G, Guzik TJ, Olofsson PS, Yin C, Weber C, Lembo G, Carnevale D, Habenicht AJR. Neuroimmune cardiovascular interfaces control atherosclerosis. Nature. 2022 May;605(7908):152-159. doi: 10.1038/s41586-022-04673-6. Epub 2022 Apr 27. PMID: 35477759.
Yuexiu District 510080 Guangzhou,China
Chuankai Zhang
Physician/Postdoctoral Fellow
I obtained my PhD from the Institute for Cardiovascular Prevention (IPEK) at Ludwig Maximilian University (LMU), where I extensively researched the complex mechanisms governing immune responses related to atherosclerosis. My research focuses on how the B cell immune response in artery tertiary lymphoid organs (ATLOs) interacts with atherosclerosis. Through this innovative work, we aim to uncover the role of ATLOs in atherosclerosis and define it as a bona fide autoimmune disease.
PUBLICATIONS
8.Y. Ran et al. Regulator of G-protein signaling 14 (RGS14) promotes cancer growth in hepatocellular carcinoma.Cancer Genetics 294-295, 80-89.doi:(2025)
7.Zhang Y, Liu G, Zeng Q, Wu W, Lei K, Zhang C, Tang M, Zhang Y, Xiang X, Tan L, Cui R, Qin S, Song X, Yin C, Chen Z, Kuang M. CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis. Cancer Cell. 2024 Aug 12;42(8):1370-1385.e9. doi: 10.1016/j.ccell.2024.07.006. PMID: 39137726.
6.Zhihua Wang, Xi Zhang, Shu Lu, Chuankai Zhang, Zhe Ma, Rui Su, Yuanfang Li, Ting Sun, Yutao Li, Mingyang Hong, Xinyi Deng, Mohammad Rafiee Monjezi, Michael Hristov, Sabine Steffens, Donato Santovito, Klaus Dornmair, Klaus Ley, Christian Weber, Sarajo K. Mohanta, Andreas J. R. Habenicht & Changjun Yin. Pairing of single-cell RNA analysis and T cell antigen receptor profiling indicates breakdown of T cell tolerance checkpoints in atherosclerosis. Nat Cardiovasc Res 2, 290–306 (2023). https://doi.org/10.1038/s44161-023-00218-w
5.Wang Z, Zhang X, Zhang C, Li Y, Lu S, Mohanta S, Weber C, Habenicht A, Yin C. Combined Single-Cell RNA and Single-Cell α/β T Cell Receptor Sequencing of the Arterial Wall in Atherosclerosis. Methods Mol Biol. 2022;2419:727-746. doi: 10.1007/978-1-0716-1924-7_44. PMID: 35237998.
4.Zhang X, Wang Z, Zhang C, Li Y, Lu S, Steffens S, Mohanta S, Weber C, Habenicht A, Yin C. Laser Capture Microdissection-Based mRNA Expression Microarrays and Single-Cell RNA Sequencing in Atherosclerosis Research. Methods Mol Biol. 2022;2419:715-726. doi: 10.1007/978-1-0716-1924-7_43. PMID: 35237997.
3.Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Borodovsky A, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, Habenicht AJR. ApoE attenuates unresolvable inflammation by complex formation with activated C1q. Nat Med. 2019 Mar;25(3):496-506. doi: 10.1038/s41591-018-0336-8. Epub 2019 Jan 28. Erratum in: Nat Med. 2019 Mar;25(3):529. doi: 10.1038/s41591-019-0378-6. PMID: 30692699; PMCID: PMC6420126.
2.Zhang C, Zhang Y, Ding W, Lin Y, Huang Z, Luo Q. MiR-33a suppresses breast cancer cell proliferation and metastasis by targeting ADAM9 and ROS1. Protein Cell. 2015 Dec;6(12):881-9. doi: 10.1007/s13238-015-0223-8. Epub 2015 Oct 27. PMID: 26507842; PMCID: PMC4656205.
1.Mohanta SK, Peng L, Li Y, Lu S, Sun T, Carnevale L, Perrotta M, Ma Z, Förstera B, Stanic K, Zhang C, Zhang X, Szczepaniak P, Bianchini M, Saeed BR, Carnevale R, Hu D, Nosalski R, Pallante F, Beer M, Santovito D, Ertürk A, Mettenleiter TC, Klupp BG, Megens RTA, Steffens S, Pelisek J, Eckstein HH, Kleemann R, Habenicht L, Mallat Z, Michel JB, Bernhagen J, Dichgans M, D'Agostino G, Guzik TJ, Olofsson PS, Yin C, Weber C, Lembo G, Carnevale D, Habenicht AJR. Neuroimmune cardiovascular interfaces control atherosclerosis. Nature. 2022 May;605(7908):152-159. doi: 10.1038/s41586-022-04673-6. Epub 2022 Apr 27. PMID: 35477759.
PUNLICATIONS